Center for Craniofacial Molecular Biology

Ostrow School of Dentistry of USC

Harold Slavkin

CSA 207 - HSC 9062
Phone: (323) 442-2216
Fax: (323) 442-2981
slavkin@usc.edu

Harold Slavkin, D.D.S.

Professor of Dentistry, Ostrow School of Dentistry of USC, University of Southern California, Los Angeles, CA

  • University of Southern California, Los Angeles, CA
    B.S.
    1961
    English/Biology

  • University of Southern California, Los Angeles, CA
    D.D.S.
    1965
    Dentistry

  • University of California, Los Angeles, CA
    Postdoc.
    1965-1966
    Anatomy

  • University of Southern California, Los Angeles, CA
    Postdoc.
    1966-1968
    Biochemistry

  • 2009 - present - Professor of Dentistry - Ostrow School of Dentistry of USC, University of Southern California, Los Angeles, CA
  • 2009 - - Sabbatical - Center for Craniofacial Molecular Biology, University of Southern California, Los Angeles, CA
  • 2000 - 2008 - Dean and G. Donald & Marian James Montgomery Professor of Dentistry - Ostrow School of Dentistry of USC, University of Southern California, Los Angeles, CA
  • 1995 - 2000 - Director - National Institute of Dental & Craniofacial Research, NIH
  • 1995 - 2000 - Lab Chief, Laboratory of Craniofacial Developmental Biology - NIAMS, NIH
  • 1990 - 1995 - George & Mary Lou Boone Professor of Craniofacial Molecular Biology - University of Southern California, Los Angeles, CA
  • 1987 - 1988 - Lady Davis Professor - Technion-Israel Institute of Technology, Haifa, Israel
  • 1987 - - Sabbatical - Department of Bioengineering, Technion University, Haifa, Israel, Professor Silbermann
  • 1979 - - Sabbatical - Department of Anatomy & Embryology, University College, London, Professor Burnstock
  • 1979 - 1980 - Visiting Scholar, Department of Anatomy & Embryology - University College London, United Kingdom
  • 1975 - 1985 - Chairman, Graduate Program in Craniofacial Biology - Graduate School, University of Southern California, Los Angeles, CA
  • 1974 - 1995 - Professor of Biochemistry - Ostrow School of Dentistry of USC, University of Southern California, Los Angeles, CA
  • 1974 - 1975 - Acting Lab Chief, Laboratory for Developmental Biology - NIDR, NIH
  • 1974 - 1975 - Sabbatical - Laboratory of Developmental Biology, NIDR, NIH, Dr. George Marting
  • 1972 - 1988 - Lab Chief, Laboratory for Developmental Biology - University of Southern California, Los Angeles, CA
  • 1971 - 1973 - Associate Professor of Biochemistry - Herman Ostrow School of Dentistry of USC, University of Southern California, Los Angeles, CA
  • 1971 - 1973 - Associate Professor of Biochemistry - Herman Ostrow School of Dentistry of USC, University of Southern California, Los Angeles, CA
  • 1968 - 1995 - Faculty, Graduate Programs Cell & Molecular Biology - University of Southern California Graduate School, Los Angeles, CA
  • 1968 - 1970 - Assistant Professor of Biochemistry - Herman Ostrow School of Dentistry of USC, University of Southern California, Los Angeles, CA
  • 2012 - Convocation Invited Speaker, International College of Dentists, October 2012
  • 2012 - NIDCR “Distinction in Public Service Award” (in appreciation of a career devoted to excellence in dental research and education), Friends of the National Institute of Dental and Craniofacial Research, National Institutes of Health, December 6th 2012
  • 2011 - Meskin/Shils Award, Dr. Edward B. Shils Entrepreneurial Fund, Annual Meeting, Union League of Philadelphia, October 18th 2011
  • 2010 - Outstanding Dental Leader Award, International College of Dentists, Annual Meeting, October 8th 2010, Orlando, Florida
  • 2009 - ADA Gold Medal Award, American Dental Association 150th Annual Meeting, Honolulu, Hawaii
  • 2008 - Honorary Professorship, Peking University, Beijing, China
  • 2008 - Honorary Member, USCs Chapter of Golden Key International
  • 2006 - William J. Gies Award, American College of Dentists
  • 2006 - Honorary Award, Hispanic Dental Association of Los Angeles
  • 2004 - Student Research Day Distinguished Scientist Award, NYU College of Dentistry
  • 2004 - Gruber Award, Greater New York Dental
  • 2002 - Callahan Memorial Award, Ohio Dental Association
  • 2002 - Honorary Doctor of Science Degree, University of Detroit Mercy School of Dentistry, Detroit, MI
  • 2001 - Fellow, American Association For The Advancement of Science (AAAS)
  • 2001 - Honorary Award, American Cleft Lip and Palate Association
  • 2001 - Honorary Award, National Ectodermal Dysplasia Foundation
  • 2001 - Fellow, American Association for the Advancement of Science (AAAS)
  • 2001 - Honorary Award, American Cleft Lip and Palate Association
  • 2001 - Visiting CATCH Professorship Award, American Academy of Pediatrics
  • 2001 - John L. Sullivan Memorial Lecture Award, University of Tennessee, Knoxville
  • 2001 - Distinguished Award of the Swedish Dental Society
  • 2000 - Prevention Research Advisory Council Award, Research America! Washington, DC
  • 2000 - Pierre Fauchard Gold Medal Award
  • 2000 - Honorary Doctor of Science Degree, University of Detroit Mercy School of Dentistry
  • 1999 - Honorary membership, American Academy of Periodontology
  • 1999 - Honorary Doctor of Science Degree, University of Connecticut Health Science Center
  • 1999 - Honorary Doctor of Science Degree, University of Medicine and Dentistry of New Jersey
  • 1999 - Honorary Doctor of Science Degree, Universit de Montral
  • 1999 - Honorary Membership, the Craniofacial Society of Great Britain
  • 1999 - Honorary Membership, American Academy of Oral Medicine
  • 1999 - Paul Goldhaber Award, Harvard School of Dental Medicine
  • 1999 - Alvin Sakler Distinguished Lecture Award in Oral Medicine
  • 1999 - Honorary Doctor of Science Degree, Universit de Montral, Canada
  • 1999 - Honorary Doctor of Science Degree, University of Medicine and Dentistry of New Jersey, Newark, NJ
  • 1999 - Honorary Doctor of Science Degree, University of Connecticut Health Center, Farmington, CT
  • 1998 - Henry Spenadel Award, 1st District Dental Society, New York
  • 1998 - Honorary Fellow, the Academy of Dentistry International
  • 1998 - Percy T. Phillips Visiting Professorship Award
  • 1998 - Special Citation - American Dental Association
  • 1997 - Honorary Doctor of Science Degree, University of Maryland at Baltimore
  • 1997 - Vincent A. Barr Professorship Award, University of Kentucky School of Dentistry
  • 1997 - Honorary Doctor of Science Degree, University of Maryland, Baltimore, Baltimore, MD
  • 1996 - Honoris Causa Award from the Universite de Paris Vth, France
  • 1996 - Elected Member, Institute of Medicine (IOM), National Academy of Sciences
  • 1996 - Annual William Thomas Green Morton Lectureship Award
  • 1996 - Alpha Omega International Dental Fraternity Achievement Medal
  • 1996 - Honoris Causa Award (Doctor of Philosophy) from the University Paris Vth
  • 1996 - 18th Marvin Goldstein Lectureship Award, Medical College of Georgia
  • 1995 - Jerome M. & Dorothy Schweitzer Research Award, Greater New York Academy of Prosthodontics
  • 1991 - Craniofacial Biology Award, International Association For Dental Research
  • 1990 - Doctorate of Science (Honorary Degree), Georgetown University, Washington, DC

  1. Slavkin HC. (2013) Reflections on my journey in biomedical research: the art, science, and politics of advocacy. J Dent Res. 2013 Jan;92(1):7-9. doi:10.1177/0022034512467035. Epub 2012 Nov 6. PubMed PMID: 23132845.

  2. Slavkin HC. (2012) Professor Clifton O. Dummett: A Lifetime of Courage (1919-2011) J Dent Res. 91:117-118.

  3. Slavkin HC. (2012) Year in Review. Inside Dentistry. 8(12):31.

  4. Slavkin HC. (2012) Evolution of the scientific basis for dentistry and its impact on dental education: past, present, and future. J Dent Educ. 2012 Jan;76(1):28-35. PubMed PMID: 22262547.

  5. Slavkin HC. (2012) The Biological Revolution Has Arrived! Are You Ready? NEXUS. (in press)

  6. Slavkin HC. (2012) Enlightened Self-Interest and Public/Private Partnerships. J Public Health Dent. 2012 Winter;72 Suppl 1:S68. doi:10.1111/j.1752-7325.2011.00302.x. PubMed PMID: 22433109.

  7. Slavkin HC. (2012) Professor Clifton O. Dummett: A Lifetime of Courage. J Dent Res. 91:117-118.

  8. Slavkin HC. (2012) The Answer Lies in the Genome. Global Health NEXUS. 14:6-15.

  9. Slavkin HC. (2012) Atlanta. CreateSpace, Georgia.

  10. Slavkin HC. (2012) Birth of a Discipline: Craniofacial Biology. Dental Aegis Communications, Newtown, Pennsylvannia.

  11. Slavkin HC. (2012) Advocacy for the 21st Century. Dimensions in Oral Hygiene. 10(12):16-17.

  12. Sakata-Goto T, Takahashi K, Kiso H, Huang B, Tsukamoto H, Takemoto M, Hayashi T, Sugai M, Nakamura T, Yokota Y, Shimizu A, Slavkin H, Bessho K. (2012) Id2 controls chondrogenesis acting downstream of BMP signaling during maxillary morphogenesis. Bone. 2012 Jan;50(1):69-78. doi: 10.1016/j.bone.2011.09.049. Epub 2011 Oct 1. PubMed PMID: 21985998.

  13. Slavkin HC, Fox CH, Meyer DM. (2011) Salivary diagnostics and its impact in dentistry, research, education, and the professional community. Adv Dent Res. 2011 Oct;23(4):381-6. PubMed PMID: 21917749.

  14. Nagata M, Nuckolls GH, Wang X, Shum L, Seki Y, Kawase T, Takahashi K, Nonaka K, Takahashi I, Noman AA, Suzuki K, Slavkin HC. (2011) The primary site of the acrocephalic feature in Apert syndrome is a dwarf cranial base with accelerated chondrocytic differentiation due to aberrant activation of the FGFR2 signaling. Bone. 2011 Apr 1;48(4):847-56. Epub 2010 Dec 1. PubMed PMID: 21129456.

  15. Slavkin HC. (2011) The Future of Dentistry. Dear Doctor Magazine 5:32-38.

  16. Iwata J, Hosokawa R, Sanchez-Lara PA, Urata M, Slavkin H, Chai Y. (2010) Transforming growth factor-beta regulates basal transcriptional regulatory machinery to control cell proliferation and differentiation in cranial neural crest-derived osteoprogenitor cells. J Biol Chem. 2010 Feb 12;285(7):4975-82. PubMed PMID: 19959467; PubMed Central PMCID: PMC2836101.

  17. Slavkin HC (2010) Leadership for Healthcare in the 21st Century: A Personal Perspective. Journal of Healthcare Leadership. 2:35-41 (on-line, open access journal)

  18. Slayton, RL and Slavkin, HC (2009) Commentary: Scientific investments continue to fuel improvements in oral health (May 2000 - Present). Academic Pediatrics. 9(6):383-385. PubMed PMID: 19945072.

  19. Snead ML, Slavkin HC. (2009) Science is the fuel for the engine of technology and clinical practice. J Am Dent Assoc. 140 Suppl 1:17S-24S. PubMed PMID:19723927.

  20. Shi S, Chai Y, Slavkin H. (2009) Emerging opportunities for the next generation of dental implants? Dent Today 28(3):98-9. PubMed PMID: 19323323.

  21. Mouradian, WE, Slayton, RL, Maas, WR, Kleinman, DV, Slavkin, HC, DePaola, D, Evans, C and Wilentz, J. (2009) Progress in children s oral health since the Surgeon General s Report on Oral Health. Academic Pediatrics, 9(6):374-379. PubMed PMID:19945070.

  22. Huang XF, Bringas P, Slavkin HC, Chai Y. (2009) Fate of HERS during Tooth Root Development. Dev. Biol. 334(1):22-30. PubMed PMID: 19576204; PubMed Central PMCID: PMC2744848.

  23. Slavkin HC. (2009) What the future holds for ectodermal dysplasias: future research and treatment directions. Am J Med Genet A. 2009 Sep;149A(9):2071-4. PubMed PMID:19681133.

  24. Murashima-Suginami A, Takahashi K, Sakata T, Tsukamoto H, Sugai M, Yanagita M, Shimizu A, Sakurai T, Slavkin HC, Bessho K. (2008) Enhanced BMP signaling results in supernumerary tooth formation in USAG-1 deficient mouse. Biochem Biophys Res Commun. 369(4):1012-6. PubMed PMID: 18329379.

  25. Slavkin HC, Navazesh M, Patel P. (2008) Basic principles of human genetics: a primer for oral medicine. In Burkets Oral Medicine. 11th edition (eds. Greenberg M, Glick M, Ship J) Hamilton, Ontario: BC Decker Inc. pp 549-568.

  26. Murashima-Suginami A, Takahashi K, Kawabata T, Sakata T, Tsukamoto H, Sugai M, Yanagita M, Shimizu A, Sakurai T, Slavkin HC, Bessho K. (2007) Rudiment incisors survive and erupt as supernumerary teeth as a result of USAG-1 abrogation. Biochem Biophys Res Commun. 359(3):549-55. PubMed PMID: 17555714.

  27. Slavkin HC, Lawrence L. (2007) Incorporating leadership knowledge and skills into the dental education community. J Dent Educ. 71(6):708-12. PubMed PMID: 17554089.

  28. Slavkin HC, Bartold PM. (2006) Challenges and potential in tissue engineering. Periodontol 2000. 41:9-15. PubMed PMID: 16686923.

  29. Sasaki T, Ito Y, Bringas Jr. P, Chou S, Urata M, Slavkin HC, Chai Y. (2006) TGF-beta-mediated FGF signaling is critical for regulating cranial neural crest cell proliferation during frontal bone development. Development 133, 371-381

  30. Sasaki T, Ito Y, Xu X, Han J, Bringas Jr P, Maeda T, Slavkin HC, Grosschedl R, Chai Y. (2005) LEF1 is a critical epithelial survival factor during tooth morphogenesis. Dev. Biol. 278,130-143.

  31. Slavkin HC. (2005) Dental student research: helping to shape the future. J Calif Dent Assoc. 33(12):945.

  32. Tan, DP, Nonaka, K, Nuckolls, GH, Liu, YH, Maxson, RE, Slavkin, HC, Shum, L. (2002) YY1 activates Msx2 gene independent of bone morphogenetic protein signaling. Nucleic Acids Res. 30:1213-1223.

  33. Takahashi, K, Nuckolls, GH, Takahashi, I, Nonaka, K, Nagata, M, Ikura, T, Slavkin, HC, Shum, L. (2001) Msx2 is a repressor of chondrogenic differentiation in migratory cranial neural crest cells. Develop. Dynamics 222:252-262.

  34. Ayres, J.A., Shum, L., Akarsu, N., Dasher, R., Takahashi, K., Ikura, T., Slavkin, H.C., and Nuckolls, G. (2001) DACH: Genomic characterization, evaluation as a candidate for postaxial polydactyly type A2, and developmental expression pattern of the murine homologue. Genomics. 77(1): 18-26.

  35. Semba I, Nonaka K. Takahashi I, Takahashi K, Dashner R, Shum L, Nuckolls G.H., and Slavkin, H.C. (2000) Positionally-dependent chondrogenesis induced by BMP4 is co-regulated by Sox9 and MSX2. Develop. Dynamics. 217:401-414.

  36. Nonaka K, Shum L, Takahashi I, Takahashi K, Ikura T, Dashner R, Nuckolls G.H., Slavkin, H.C. (1999) Convergence of the BMP and EGF Signaling Pathways on Smad1 in the Regulation of Chrondrogenesis. Int. J. of Develop. Biol. 43:795-807

  37. Nuckolls G.H., Shum L., Slavkin H.C. (1999) Progress Towards Understanding Craniofacial Malformations. The Cleft Palate Craniofacial Journal. 36(1)12-26.

  38. Kobayashi S, Satomura K, Levsky J.M., Sreenath T, Wistow G.J., Semba I, Shum L, Slavkin HC, and Kulkarni A.B. (1999) Expression Pattern of Macrophage Migration Inhibitory Factor During Embryogenesis. Mechanisms of Development 84:153-156.

  39. Miettinen PJ, Chin JR, Shum L, Slavkin HC, Shuler C, Derynck R, and Werb Z. (1999) Epidermal Growth Factor Receptor Function is Necessary for Craniofacial Development and Palate Closure. Nature Genetics. 22:69-73.

  40. Takahashi I, Nuckolls GH, Takahashi K, Tanaka O, Semba I, Dashner R, Shum L, and Slavkin HC. (1998) Compressive Force Induces Sox9, Type II Collagen and Aggrecan and Inhibits IL1- Expression Resulting in Chondrogenesis in Mouse Embryonic Limb Bud Mesenchymal Cells. J. Cell Sci. 111:2067-2076.

  41. Takahashi K, Nuckolls G, Tanaka O, Semba I, Takahashi I, Dashner R, Shum L, Slavkin, H.C. (1998) Adenovirus Mediated Ectopic Expression of Mxs2 in Even-Numbered Rhombomeres Induces Apoptotic elimination of Cranial Neural Crest Cells in Ovo. Development. 125:1627-1635

  42. Chai Y, Sasano Y, Bringas P Jr., Mayo M, Slavkin H.C., Shuler, C. (1997) Characterization of the Fate of Medial Epithelial Cells During the Fusion of Mandibular Prominances in vivo. Developmental Dynamics 208:526-535

  43. Sadler TW, Melissa R, Slavkin HC, Lauder J, Maness P, Linney E, Sulik K, Mirkes P. (1997) Growth and Differentiation Factors. Reproductive Toxicology 11(2-3): 331-337

  44. Chai, Y., Mah, A., Crohin, C., Groff, S., Bringas, P., Le, T., Santos, V. and Slavkin, H. C. (1994) Specific transforming growth factor-beta subtypes regulate embryonic mouse Meckel's cartilage and tooth development. Develop. Biol. 162:85-103.

  45. Shum, L., Sakakura, Y., Bringas, Jr., P., Luo, W., Snead, M. L., Mayo, M., Crohin, C., Millar, S., Werb, Z., Buckley, S., Hall, F.L., Warburton, D. and Slavkin, H.C. (1993) EGF abrogation induced fusilli-form dysmorphogenesis of Meckel's cartilage during embryonic mouse mandibular morphogenesis in vitro. Development, 118:903-917.

  46. Slavkin, H.C. (1993) Reigers syndrome revisited: Experimental approaches using pharmocologic and antisense strategies to abrogate EGF and TGF-alpha functions resulting in dysmorphogenesis during embryonic mouse craniofacial morphogenesis. Am. J. of Med. Genetics, 47:689-697.

  47. Ferguson, M.W.J., Honig, L.S. and Slavkin, H.C. (1984) Differentiation of cultural palatal shelves from alligator, chick, and mouse embryos. Anat. Rec. 209(2): 231-249.

  48. Slavkin, H.C., Bringas, P., Jr., Cummings, E. and Grodin, M.S. (1982) Initiation of quail and mouse mandibular chondrogenesis and osteogenesis in a serumless, chemically-defined medium. Calcif. Tissue. Int. 34:111-112.

  49. Melnick, M., Jaskoll, T. and Slavkin, H.C. (1981) Corticosteriod-induced cleft palate in mice and H-2 haplotype material and embryonic effects. Immunogenetics, 13:443-450.

  50. Melnick, M., Jaskoll, T. and Slavkin, H.C. (1981) The association of H-2 haplotype with implantation, survival, and growth of murine embryos. Immunogenetics, 14:303-308.